HORDB

ID: hor005225
Uniprot ID: P01260
Protein name: Calcitonin
Gene name: CALCA
Organism: Bos taurus (Bovine)
Family: Calcitonin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Mechanism: NA
Cross BBB: NA
Target: RAMP1, CALCRL
Target Unid: F1MLY6, A6QP74
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P01260-F1.pdb

hor005225_AF2.pdb

hor005225_ESM.pdb

Mass:	414913	Formula:	C159H232N42O48S3
Absent amino acids:	IQ	Common amino acids:	S
pI:	7.25	Basic residues:	3
Polar residues:	16	Hydrophobic residues:	8
Hydrophobicity:	-36.56	Boman Index:	-4297
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	1337.81	Extinction Coefficient cystines:	8605
Absorbance 280nm:	277.58